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, Jasmin Krismer Department of Chemistry and Applied Biosciences (D-CHAB), ETH Zurich , Zurich, Switzerland Search for other works by this author on: Oxford Academic Manu Tamminen Eawag, Swiss Federal Institute of Aquatic Science and Technology , Dubendorf, Switzerland Department of Environmental Systems Science, ETH Zurich , Zurich, Switzerland Search for other works by this author on: Oxford Academic Simone Fontana Eawag, Swiss Federal Institute of Aquatic Science and Technology , Dubendorf, Switzerland Search for other works by this author on: Oxford Academic Renato Zenobi Department of Chemistry and Applied Biosciences (D-CHAB), ETH Zurich , Zurich, Switzerland Correspondence: R Zenobi, Institute for Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland. E-mail: zenobi@org.chem.ethz.ch Search for other works by this author on: Oxford Academic Anita Narwani Eawag, Swiss Federal Institute of Aquatic Science and Technology , Dubendorf, Switzerland Correspondence: A Narwani, BU-G11 Überlandstrasse 133, Department of Aquatic Ecology, Eawag (Swiss Federal Institute of Aquatic Science and Technology), 8600 Dübendorf, Switzerland. E-mail: anita.narwani@eawag.ch Search for other works by this author on: Oxford Academic
The ISME Journal, Volume 11, Issue 4, April 2017, Pages 988–998, https://doi.org/10.1038/ismej.2016.167
Published:
09 December 2016
Article history
Received:
15 June 2016
Revision received:
05 September 2016
Accepted:
16 September 2016
Published:
09 December 2016
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Jasmin Krismer, Manu Tamminen, Simone Fontana, Renato Zenobi, Anita Narwani, Single-cell mass spectrometry reveals the importance of genetic diversity and plasticity for phenotypic variation in nitrogen-limited Chlamydomonas, The ISME Journal, Volume 11, Issue 4, April 2017, Pages 988–998, https://doi.org/10.1038/ismej.2016.167
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Abstract
Phenotypic variation is vital for microbial populations to survive environmental perturbations. Both genetic and non-genetic factors contribute to an organism’s phenotypic variation and therefore its fitness. To investigate the correlation between genetic diversity and phenotypic variation, we applied our recently developed mass spectrometry method that allows for the simultaneous measurement of more than 25 different lipids and pigments with high throughput in the unicellular microalga Chlamydomonas reinhardtii. We monitored the impact of nitrogen limitation on a genetically diverse wild-type strain CC-1690 and two isoclonal isolates from CC-1690 named ANC3 and ANC5. Measuring molecular composition of thousands of single cells at different time points of the experiment allowed us to capture a dynamic picture of the phenotypic composition and adaptation of the populations over time. Although the genetically diverse population maintained phenotypic variation over the whole time course of the experiment, the isoclonal cultures showed higher synchronicity in their phenotypic response. Furthermore, the genetically diverse population showed equal or greater phenotypic variation over the whole time range in multidimensional trait space compared with isoclonal populations. However, along individual trait axes non-genetic variance was higher in isoclonal populations.
© International Society for Microbial Ecology 2017
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
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